A weekend in Florence would be great in October - weather still good and crowds slowly decreasing.
As long as you stay in the historical center, you will be walking distance from all of the sights.
You can browse through here: http://www.florenceaccommodation.com/
but in particular I would recommend
Casa dei Tintori
Antica Dimora Johlea
Antica Dimora Firenze
or Hotel Principe
They vary so take a look and see which one appeals more... if you tell me which one(s) you like and need more recommendations, I'll go from what you tell me are your preferences. Ciao for now!