Buongiorno,
You most certainly can enjoy Tuscany by staying in Florence and hiring a driver to take you around the countryside - and if you are truly out to enjoy the wine and great food, then I couldn't suggest a better way to do that.
As for accommodations, you might like looking at Villa Antea, https://www.visitflorence.com/floren...residence.html or even Antica Dimora Fiorentina
There are several places close by in the Florentine hills that you can read reviews on at our site, Viticcio, Torre a Cona and Villa Medici Lilliano are some of my favorites.
In this section we suggest several itineraries, have a look to see what your options are and the different areas to explore,
https://www.discovertuscany.com/what.../wine-tasting/
Don't forget to look into Arezzo as well as Lucca for wines (and great food!!)
Buon Viaggio,
Donna Denise
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