Buongiorno,
Obviously, someone who doesn't "have" to use a wheelchair may not notice all the nuances and difficulties about getting around with one but, I hope to reassure you just a bit.
Most major sites - and transport - have to make accommodations for those who have difficulty traveling. The main train stations have elevators to take you from track to track and museums all have facilities for moving those with wheelchairs from place to place. It may make your life easier if you may want to book with a guide who can take care of the logistics.
This article also provides more detailed information for the Uffizi:
http://www.visituffizi.org/museum/services/
and this article confirms the mobility in the Galleria dell'Accademia:
http://www.accademia.org/plan-your-visit/
I had friends arrive with their elderly parents - and we did a whirlwind tour of Pisa and Lucca with an NCC (a driver with his own vehicle) and he knew just where to go to ease us into the sites, and it was well worth it. You could look into hiring a driver for a day or two to really enjoy the small towns, vineyards and landscape. (here are two suggestions, and they both speak English and I have worked with both. You can reach out to them with WhatsApp: Simone - +39 334 7053211 or Beppe - +39 392 1400056)
When booking in the countryside - be sure to ask how accessible the accommodations are, many times things are not on the ground floor. Though by law, larger hotels and agriturismo (farmhouse accommodations) have to have a place that will accommodate wheelchairs.
You will find that many restaurants are also prepared to accept wheelchairs, so no worries about eating! (Even the little tiny restaurant by my house in the deep countryside has a ramp for a wheelchair)
For more info, try reading this article:
https://www.visitflorence.com/moving...isability.html
Buon Viaggio,
Donna Denise
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