Ciao Scotti,
If this is the first time you're in Tuscany, you'll have to hit all of the must-sees, from Florence to Siena to Pisa. What area are your lodgings in, in the Mugello valley? It will be very easy to move around for day trips as well as just staying in and relaxing and enjoying the local area. If you let me know where you are, I can offer more ideas for local places to discover, such as Scarperia in the Mugello but also the Bosco ai Frati convent or Montesenario, just as an example.